Behavioral and metabolic characterization of heterozygous and homozygous POLG mutator mice
نویسندگان
چکیده
منابع مشابه
Correction: Behavioral and Electrophysiological Characterization of Dyt1 Heterozygous Knockout Mice
The following information is missing from the Funding section: This study was supported by the Bachmann-Strauss Dystonia and Parkinson Foundation, Inc. The complete, correct funding information is as follows: This work was supported by Tyler’s Hope for a Dystonia Cure, Inc., Dystonia Medical Research Foundation, Bachmann-Strauss Dystonia and Parkinson Foundation, Inc., National Institutes of He...
متن کاملBehavioral and Electrophysiological Characterization of Dyt1 Heterozygous Knockout Mice
DYT1 dystonia is an inherited movement disorder caused by mutations in DYT1 (TOR1A), which codes for torsinA. Most of the patients have a trinucleotide deletion (ΔGAG) corresponding to a glutamic acid in the C-terminal region (torsinA(ΔE)). Dyt1 ΔGAG heterozygous knock-in (KI) mice, which mimic ΔGAG mutation in the endogenous gene, exhibit motor deficits and deceased frequency of spontaneous ex...
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ماکروسیکلهای شیف باز از اهمیت زیادی در شیمی آلی و دارویی برخوردار می باشند. این ماکروسیکلها با دارابودن گروه های مناسب در مکانهای مناسب می توانند فلزاتی مثل مس، نیکل و ... را در حفره های خود به دام انداخته، کمپلکسهای پایدار تولید نمایند. در این پایان نامه ابتدا یک دی آلدئید آروماتیک از گلیسیرین تهیه می شود و در مرحله بعدی واکنش با دی آمینهای آروماتیک و یا آلیفاتیک در رقتهای بسیار زیاد منجر به ت...
15 صفحه اولPolg mutator phenotype does not cause dopaminergic neurodegeneration in DJ - 1 deficient mice " DJ - 1 deficient mice with Polg mutator phenotype
The authors declare no competing financial interests. DNH and MRC designed research. DNH, CTP, and RK performed research. DNH, CTP, RGL, and MRC analyzed data. DNH, CTP, and MRC wrote the paper. Funding sources. This research was supported entirely by the Intramural Research Program of the NIH, National Institute on Aging. Correspondence should be addressed to: Dr. Mark R Cookson, Cell Biology ...
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Mice lacking all pro-opiomelanocortin (POMC)-derived peptides have been created by gene targeting of the POMC locus in embryonic stem cells. Phenotypes of the POMC null homozygous mutants include obesity, pigmentation defects, and adrenal insufficiency. Here, we report that both POMC null homozygous and heterozygous mutants also develop pituitary gland tumors, which result in their premature de...
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ژورنال
عنوان ژورنال: Mitochondrion
سال: 2013
ISSN: 1567-7249
DOI: 10.1016/j.mito.2013.03.006